Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8920223 | Current Opinion in Toxicology | 2018 | 18 Pages |
Abstract
Macromolecule oxidation in response to reactive oxygen species (ROS) is associated with a variety of diseases. The recognition of NO as a key regulator of redox signalling has more recently led to the discovery that reactive nitrogen species (RNS) also elicit modifications of macromolecules which are also involved in pathophysiological processes. This article provides an overview of key biomarkers used to assess oxidation, peroxidation and nitration/nitrosation signalling, stressing the necessity to analyse multiple biomarkers to understand the redox mechanisms involved in biological responses.
Keywords
ACRTBARSOMPN2O3LPODNPNrf2MDAS-nitrosation(NO)4-ONE4-HNEFRRUPRRNSHRVNO+O2−ONOO−ROSAntioxidantsAcroleinNitro-oxidative stressPolyunsaturated fatty acidsPUFAALEtrans-4-Hydroxy-2-nonenalDinitrogen trioxideOxidative stressSuperoxideRedox signallingnuclear factor (erythroid-derived 2)-like 2LOOHLOOlipid peroxyl radicalmalondialdehydeCopper,zinc-superoxide dismutaseCu,Zn-SODthiobarbituric acid reactive substancesBiomarkersheart rate variabilityTyrosine nitrationNitric oxideLipid hydroperoxideFree radical reactionUnfolded protein responseLipid peroxidationprotein kinase RNA-like endoplasmic reticulum kinasePeroxynitritePERKProtein carbonylationreactive nitrogen speciesReactive oxygen speciesSuperoxide ionNitrosonium ion
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Authors
Ana Cipak Gasparovic, Neven Zarkovic, Serge P. Bottari,