The membrane mesenchymal stem cell derived conditioned medium exerts neuroprotection against focal cerebral ischemia by targeting apoptosis

Article ID	Journal	Published Year	Pages	File Type
8943760	Journal of Chemical Neuroanatomy	2018	28 Pages	PDF

Abstract

The results of this study indicate that treatment with AMSC-CM improves the pathological effects in the acute phase of cerebral ischemia. These findings establish a substantial foundation for stroke therapy and future research.

Keywords

α-MEM tPA TTC CBF IGF-1 ICV FITC ECA ICA MCAO LDF FBS DMEM IL-6 RBCs FACS HGF PBS BBT CCA Red blood cells Dulbecco's modified Eagle's medium ROS α-Minimal essential medium EDTA Ethylenediaminetetraacetic acid middle cerebral artery occlusion insulin-like growth factor-1 Focal cerebral ischemia interleukin 6 Evans Blue cerebral blood flow Apoptosis fluorescence-activated cell sorting blood brain barrier BBB fetal bovine serum Mesenchymal stem cells Conditioned medium external carotid artery internal carotid artery common carotid artery Hepatocyte growth factor Vascular endothelial growth factor Vascular Endothelial Growth Factor (VEGF)phycoerythrin Phosphate buffered saline tissue plasminogen activator fluorescein isothiocyanate laser Doppler flowmetry Nitric oxide Reactive oxygen species

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry

The membrane mesenchymal stem cell derived conditioned medium exerts neuroprotection against focal cerebral ischemia by targeting apoptosis

Authors

Masoumeh Faezi, Solmaz Nasseri Maleki, Nahid Aboutaleb, Mahin Nikougoftar,