| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8949318 | Biochimica et Biophysica Acta (BBA) - General Subjects | 2018 | 10 Pages |
Abstract
This study provides a fresh framework for understanding the seemingly contradictory effects of selenium supplementation. In addition, it offers a novel explanation of how physiologic upregulation of ferroptosis and downregulation of selenoprotein synthesis may mediate resolution of inflammation and carcinogenesis. This is of therapeutic significance.
Keywords
GSRSASPTfR2GCLMH2AXBcl-2 homologous antagonist/killerCeruloplasminGPx4SOD2CHAC1bcl-2-like protein 4S1PIL-22Grx3TNFαH2A histone family member XATF4SRXN1Nrf2Txnrd1Bcl-2cox2Mtf1Sp-1Trx1Sphingosine-1 phosphateCSAInterleukin-22Baxtumor necrosis factor alphathioredoxinsulfiredoxin-1Superoxide dismutase 2Cyclosporine Acyclooxygenase 2Vascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)activating transcription factor 4B-cell lymphoma 2Specificity protein 1BAKBokInterferon gammaglutathione reductaseglutathione peroxidase 4Transferrin receptor 2transferrin receptor 1
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Authors
Jack L. Arbiser, Michael Y. Bonner, Nicole Ward, Justin Elsey, Shikha Rao,