Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8956043 | Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology | 2018 | 6 Pages |
Abstract
We investigated the standard metabolic rate and liver mitochondria metabolism of the southern catfish when exposed to waterborne cadmium. Juvenile southern catfish were exposed to waterborne cadmium concentrations (0, 62.5, 125, 250 and 500â¯Î¼g/L, respectively) for 8â¯weeks, and the final body mass, the standard metabolic rate, the state III respiration rate, the activity of cytochrome C oxidase (CCO) of liver mitochondria, and the hepatosomatic index (HSI) were determined. The results showed that the 62.5â¯Î¼g/L, 125â¯Î¼g/L, and 250â¯Î¼g/L experiment groups had a significantly higher standard metabolic rate than that of the control group. Standard metabolic rate in the 500â¯Î¼g/L experiment group did not differ from the control group. State III respiration rate of liver mitochondria decreased with an increase in cadmium concentration. The 125â¯Î¼g/L, 250â¯Î¼g/L, and 500â¯Î¼g/L experiment groups had a significantly lower state III respiration rate than that of the control group. The activity of CCO in the 500â¯Î¼g/L experiment group was significantly lower than that of the control group. These results suggest that at low cadmium concentrations, the southern catfish could continuously improve the standard metabolism to provide extra energy in response to the cadmium stress. Cadmium exposures caused damage to the structure and function of liver mitochondria and decreased the activity of mitochondria enzymes, which results in a decrease in the energy of the liver metabolism. The adjustment of the metabolism of liver mitochondria in southern catfish was inconsistent with the adjustment of individual standard metabolism.
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Authors
Jian Li, Xiaojun Xie,