Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8956547 | Journal of Drug Delivery Science and Technology | 2018 | 41 Pages |
Abstract
Folate-targeted and near-infrared(NIR)-triggered nanoparticles have been developed to enhance the tumor-targeting drug transportation and minimize the severe side effects along with the chemotherapy. By doping with indocyanine green (ICG), the PEGylated platinum(IV)-prodrug plus 5-fluorouracil co-loaded nanoparticles had nanosized spherical structure which was comprised of a poly(d,l-lactide-co-glycolide) (PLGA) core, a composite layer of soybean lecithin mixed with PEGylated phospholipid, and a folate-targeted ligand to actively recognize tumors. Upon laser irradiation, the nanoparticles showed enhanced receptor-mediated cellular uptake and highly effective chemo-photothermal combination therapy of ovarian cancer.251
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Authors
Yu Sun, Tianyi Shi, Yuyan Zhou, Lingyun Zhou, Baiwang Sun,