Evolution of metabolic syndrome and its biomarkers

While initially contemplated to be an endocrine problem associated with insulin resistance, the scientific insight about this pathology has undergone a gradual evolution. Therefore the pathogenic and consequent diagnostic modality consistently changed. Quite fascinatingly its phenomenal conversion from an endocrine etiopathology to an inflammatory pathogenesis has imprinted a paradigm shift. From laboratory medicine perspective, these evidences have immense impact to steer the research towards development of the apposite diagnostic modality for this very significant and nationally relevant health problem.