Capillary electrophoretic mobility shift displacement assay for the assessment of weak drug-protein interactions

Article ID	Journal	Published Year	Pages	File Type
8961138	Analytica Chimica Acta	2018	9 Pages	PDF

Keywords

Nafamostat BGE PEG 6000 FBDD PPACK NAFA ACE IC50 Percentage of inhibition HPAC NAPAP RSD nuclear magnetic resonance DMSO affinity capillary electrophoresis background electrolyte relative standard deviation Benzamidine Electrophoretic Mobility Tris(hydroxymethyl)aminomethane hydrochloride Binding assay NMR Surface plasmon resonance SPR Inhibitory constant Dapa Dimethylsulfoxide Migration time AGB half maximal inhibitory concentration poly(ethylene oxide)Polyethylene glycol 6000 PEO High performance affinity chromatography Fragment-based drug discovery Fragment based drug discovery quality control

Related Topics

Physical Sciences and Engineering Chemistry Analytical Chemistry

Capillary electrophoretic mobility shift displacement assay for the assessment of weak drug-protein interactions

Authors

E. FarcaÅ, J. Hanson, L. Pochet, M. Fillet,