Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8961965 | Peptides | 2018 | 9 Pages |
Abstract
Contractile responses to angiotensin II are preserved in narrow lumen human cirrhotic splanchnic arteries and are comparatively augmented in early disease. Angiotensin-(1-7) had no vasodilatory effect on adrenergic tone, however, attenuated angiotensin II-induced contractility, possibly through an Ang-(1-7)-AT1R interaction, and thus may contribute to pathological vasodilatation in human cirrhosis.
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Authors
Stephen Casey, Chandana Herath, Indu Rajapaksha, Robert Jones, Peter Angus,