Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8964136 | Microbial Pathogenesis | 2018 | 21 Pages |
Abstract
Lateral gene transfer (LGT) has been demonstrated as a transfer process of novel genes between different species. LGT proceedings are occurring between microbes and plants, as well as between microbes and animals. New evidence demonstrates that bacterial insertional mutagenesis may occur in cancer cells. Due to the important role of genetic changes in the increase of cell proliferation and cancer development, we reviewed the effects of microbial-animal LGT in human oncogenesis. In addition, viral DNA can induce cancer development by random insertion into cancer-related genes or by inducing translocations. In conclusion, growing evidence shows the contribution of the microbial genome in cancer and autoimmune disease.
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Authors
Naser Alizadeh, Mir Naser Seyyed Mousavi, Farid Hajibonabi, Mohammad Yousef Memar, Bahareh Mehramuz, Khalil Aziziyan, Somayeh Shiralizadeh, Mehdi Yousefi, Hossein Samadi Kafil,