| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8965530 | Biochemical and Biophysical Research Communications | 2018 | 6 Pages |
Abstract
Norepinephrine downregulates GLT-1 mRNA expression in astrocytes via the α1-adrenoceptor. Our results provide new insight into the mechanisms involved in downregulation of GLT-1 in the chronic pain models.
Keywords
SNIGLT-1DMEMFBSPWTDAPIGFAPGAPDH4′,6-diamidino-2-phenylindoleDulbecco's modified Eagle's mediumpaw withdrawal thresholdAstrocyteSpared nerve injuryEDTAEthylenediaminetetraacetic acidanalysis of varianceANOVAEnzyme-linked immunosorbent assayELISAGlutamate transporterstandard error of the meanNeuropathic painfetal bovine serumSpinal cordSEMnorepinephrinepolymerase chain reactionPCRanti-glial fibrillary acidic proteinglutamate transporter-1glyceraldehyde 3-phosphate dehydrogenase
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Authors
Masako Kurita, Yoshikazu Matsuoka, Kosuke Nakatsuka, Daisuke Ono, Noriko Muto, Ryuji Kaku, Hiroshi Morimatsu,