Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8969065 | Tuberculosis | 2005 | 9 Pages |
Abstract
Although different templates had to be used to model the MceA proteins, functional information may be derived that is relevant for their overall function in M. tuberculosis. The β-domain is probably involved in binding with the receptors on target cells while the α-domain is more likely to be involved in pore formation. As predicted from the folds, Mce3A and Mce4A model structures indicate a lipid bound conformation and therefore may be required in signaling events of the mammalian cell entry process.
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Authors
D. Mitra, B. Saha, D. Das, H.G. Wiker, A.K. Das,