Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8993344 | Il Farmaco | 2005 | 6 Pages |
Abstract
A simple, convenient and straightforward synthesis of 3-aryl-1,2,4-oxadiazoles 4a-f from arylamidoximes 1a-f and palmitic acid 2 is described. Compounds 4a-f are non-lethal in mice at four times the therapeutic dose (i.p., LD50 > 1 g kg-1 of the animals' body weight). These heterocycles have been found to possess antiinflammatory property similar to aspirin and ibuprofen. Three compounds, viz., 4a, d, e have also been evaluated for antitumor activity, where 4d exhibited an excellent activity comparable to lapachol.
Related Topics
Health Sciences
Pharmacology, Toxicology and Pharmaceutical Science
Drug Discovery
Authors
Natércia M. Miranda Bezerra, Shalom P. De Oliveira, Rajendra M. Srivastava, Joel R. Da Silva,