Study of electrochemical oxidation and determination of albendazole using a glassy carbon-rotating disk electrode

In this work, electrochemical oxidation of albendazole (ABZ) was carried out using a glassy carbon-rotating disk electrode. Development of electroanalytical methodology for ABZ quantification in pharmaceutical formulations was also proposed by using linear sweep voltammetric technique. Electrochemical oxidation is observed for ABZ at E1/2 = 0.99 V vs. Ag/AgClsat, when an anodic wave is observed. Kinetic parameters obtained for ABZ oxidation exhibited a standard heterogeneous rate constant for the electrodic process equal to (1.51 ± 0.07) × 10-5 cm s-1, with a αna value equal to 0.76. Limiting current dependence against ABZ concentration exhibited linearity on 5.0 × 10-5 to 1.0 × 10-2 mol l-1 range, being obtained a detection limit of 2.4 × 10-5 mol l-1. Proposed methodology was applied to ABZ quantification in pharmaceutical formulations.