| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8993400 | Il Farmaco | 2005 | 5 Pages |
Abstract
A series of 2-semicarbazonomethyl-4,5-methylenedioxyphenylacetic acids (12-19) were synthesized and tested as anticonvulsant agents in DBA/2 mice against sound-induced seizures and the results compared to those previously reported for the corresponding methyl esters (4-11). The new compounds possess anticonvulsant properties lower than those of 4-11, but, in some instances, comparable to that of GYKI 52466, a well-known noncompetitive AMPA receptor antagonist.
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Authors
Nicola Micale, Maria Zappalà , Giuseppe Zuccalà , Frank S. Menniti, Guido Ferreri, Giovambattista De Sarro, Silvana Grasso,