| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8993401 | Il Farmaco | 2005 | 4 Pages |
Abstract
Novel 2-alkylsulfanyl-1-benzyl-5-imidazolecarboxylic acid hydrazides (15a,b) were synthesized as analogues of isocarboxazide, which is a known nonselective irreversible monoamine oxidase inhibitor and tested for monoamine oxidase A and B inhibitory activity. Neither of the compounds showed any inhibition of MAO B activity up to a high concentration of 100 μM. An MAO A activity was only slowly inhibited at this high concentration after prolonged incubation with either compound. This suggests any observed inhibition is not very specific.
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Authors
Farzin Hadizadeh, Razieh Ghodsi,