Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8993417 | Il Farmaco | 2005 | 6 Pages |
Abstract
In this research, the effect of mucoadhesive polymers such as hydroxyl propyl methyl cellulose (HPMC) with viscosity grade 60 and 500Â mPas, sodium carboxy methyl cellulose (NaCMC) and carbopol 934 (Cp 934) alone or in combination with each other on the release profile of prednisolone was studied and mucoadhesion strength of these buccoadhesive formulations was evaluated. The results showed that the release of prednisolone from HPMC with viscosity grade 60Â mPas and Cp 934 alone was fast and their mucoadhesion strengths was low. On the other hand, the release rates of prednisolone from the HPMC viscosity grade 500Â mPas and NaCMC and mucoadhesion strengths were moderate and suitable. The results showed that with different blends of HPMC viscosity grade 500Â mPas or NaCMC and Cp 934 with increasing in HPMC or NaCMC/Cp 934 ratio a remarkable decrease in the rate of drug release and an appreciable increase in the mucoadhesion strength was observed. Except from the formulations prepared with HPMC viscosity grade 60 and 500Â mPas, other formulation had more fluctuations in release profiles and their kinetics of release were not fitted to zero order model.
Related Topics
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Pharmacology, Toxicology and Pharmaceutical Science
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Authors
Soliman Mohammadi-Samani, Rahim Bahri-Najafi, Golamhosein Yousefi,