Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8993442 | Il Farmaco | 2005 | 7 Pages |
Abstract
The preparation and electrochemical characterization of a carbon paste electrode modified with bis(N,N-piperidinedithiocarbamate)-μ-tris(N,N-piperidinedithiocarbamate)diruthenium(III) complex, α-[Ru2(Pip)5]Cl are described. The best voltammetric response was obtained for a 10% (m/m) α-[Ru2(Pip)5]Cl content in the paste, potassium acid phthalate solution pH 4.0 as supporting electrolyte and scan rate of 100 mV s-1. The analytical potentialities of the electrode have been evaluated using l-ascorbic acid (vitamin C) as a probe. A sensitive linear voltammetric response for l-ascorbic acid was obtained in the concentration range 4.50-113 Ã 10-5 mol l-1 (7.92-200 mg l-1) with a slope of 1.12 Ã 104 μA mol-1, and a detection limit (3Ï/slope) of 7.00 Ã 10-6 mol l-1 using cyclic voltammetry. The concentrations of l-ascorbic acid in pharmaceutical formulations (tablets and liquid) were determined using the modified electrode and compared with an iodimetric procedure with good agreement at the 95% confidence and relative error lower than 1%.
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Authors
Luiz Antônio Ramos, Ãder Tadeu Gomes Cavalheiro, Gilberto Orivaldo Chierice,