Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8993469 | Il Farmaco | 2005 | 5 Pages |
Abstract
New racemic 1,4-disubstituted piperazines chemically named ethyl 2-[(4-pyrimidin-2yl-piperazine-1yl)carbonyl]C3-C5-alkanoates 1-7 were synthesized. The compounds were resolved into enantiomers on cellulose tris(4-methylbenzoate) and amylose tris(3,5-dimethylphenylcarbamate) stationary phases using hexane/propan-2-ol mobile phases. The optimum separation conditions for the compounds were obtained on cellulose tris(4-methylbenzoate) with 5% of 2-propanol in hexane. The relationship between structural and chromatographic parameters is discussed.
Keywords
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Authors
ZdzisÅaw Chilmonczyk, Åukasz Sienicki, Bożena Åozowicka, MaÅgorzata Lisowska-Kuźmicz, Anna JoÅczyk, Hassan Y. Aboul-Enein,