Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8993479 | Il Farmaco | 2005 | 4 Pages |
Abstract
A Fourier transform infrared (FT-IR) spectrometric method was developed for the rapid, direct measurement of dehydropeiandrosterone. Conventional KBr spectra and KBr + 2.0Â mg microcrystalline cellulose (MCC) spectra were compared for best determination of active substance in drug formulation. Two chemometric approaches, partial least-squares (PLS) and principal component regression (PCR+) methods were used in data processing. The best results were obtained with PCR+ method.
Related Topics
Health Sciences
Pharmacology, Toxicology and Pharmaceutical Science
Drug Discovery
Authors
Andrei A. Bunaciu, Hassan Y. Aboul-Enein, Åerban Fleschin,