Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8994251 | Journal of Drug Delivery Science and Technology | 2005 | 6 Pages |
Abstract
To administer individualised nifedipine doses to hypertensive children, Adalat retard 10Â mg modified release (m/r) tablets are, in practice, cut if the child can swallow or crushed and suspend in water to produce a liquid formulation. We showed that the cutter used did not produce even halves or quarters tablets. Drug release and dissolution rate increased when tablets were cut into halves, quartered and crushed. The extemporaneous suspension (1Â mg/ml) started to degrade after 15Â min under light and it was difficult to withdraw targeted doses (1 and 5Â mg) from this very unstable dispersion. Imported nifedipine drops (20Â mg/ml) were easier to manipulate and provided more reproducible dosing although toxicity of the vehicle (magrogol 200) in children is unknown. This work illustrates the lack of appropriate paediatric drug formulations for children which is a rate limiting step for effective clinical use and for the development of optimal dose guidelines.
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Authors
C. Tuleu, J. Grangé, S. Seurin,