Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8994830 | Journal of Pharmaceutical Sciences | 2005 | 11 Pages |
Abstract
Glass dynamics as measured by Ï could not explain the stability results. Stability correlated best with the preservation of native structure for sucrose-based formulations, but with the trehalose-based formulation, neither structural relaxation time nor extent of native structure was predictive of stability. However, it is possible that the β-relaxations rather than the α-relaxation (i.e., the Ï we measured) is critical to the stability. Plasticizers like glycerol may decrease Ï for “α-motion” but increase Ï for “β-motion” and stabilize proteins (Cicerone MT, Tellington A, Trost L, Sokolov A, 2003, BioProcess Inter 1:1-9). © 2005 Wiley-Liss, Inc. and the American Pharmacists Association
Keywords
Related Topics
Health Sciences
Pharmacology, Toxicology and Pharmaceutical Science
Drug Discovery
Authors
Liuquan (Lucy) Chang, Deanna Shepherd, Joanna Sun, Xiaolin (Charlie) Tang, Michael J. Pikal,