Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9001705 | Biochemical Pharmacology | 2005 | 9 Pages |
Abstract
Prodigiosin (PDG), a bacterial metabolite, is a known T cell-specific immunosuppressant. Here, we compared its inhibitory potency and mode of action with cyclosporine A (CsA) in a mouse model. PDG efficiently inhibited T cell proliferation with an IC50 of 3.37 ng/ml, a similar dose to that of CsA (IC50 of 2.71 ng/ml). PDG inhibited only IL-2Rα expression, but not IL-2 expression, whereas CsA inhibited both. Exogenously added IL-2 reversed the suppressive activity of CsA, but not that of PDG. Moreover, although both PDG and CsA markedly reduced mortality rates in lethal acute graft-versus-host disease (GVHD), the combined treatment was more effective than either drug alone. These results demonstrate that PDG and CsA have similar inhibitory potencies, but different modes of action, and suggest that PDG has potential use as a supplementary immunosuppressant in combination with CsA for the treatment of GVHD.
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Authors
Sang-Bae Han, Chang Woo Lee, Yeo Dae Yoon, Jong Soon Kang, Ki Hoon Lee, Won Kee Yoon, Young Kook Kim, Kiho Lee, Song-Kyu Park, Hwan Mook Kim,