| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9001811 | Biochemical Pharmacology | 2005 | 8 Pages |
Abstract
This study shows that the antioxidative effects of curcumin are preceded by an oxidative stimulus, which is time and dose-dependent. Excessive concentrations of curcumin may even harm cells, as cell viability was decreased, in spite of elevated GSH contents. There was no clear relationship between intracellular GSH concentrations and the anti-inflammatory effects of curcumin.
Keywords
GSSGEMSAGSHtphorbol 12-myristate 13-acetateBSOGSHMCFLPSDMSOPMANFκBROSElectrophoretic mobility shift assayAntioxidativebuthionine sulfoximinetumor necrosis factor-alphaDimethyl sulfoxideAnti-inflammatoryTNF-αnuclear factor kappa Blipopolysaccharidemean channel fluorescenceCurcuminGlutathioneglutathione disulfidetotal glutathioneReactive oxygen species
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Authors
Eva-Maria Strasser, Barbara Wessner, Nicole Manhart, Erich Roth,