Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9001977 | Biochemical Pharmacology | 2005 | 9 Pages |
Abstract
Jurkat/TP cells showed weak phosphorylation of Bcl-2, and kinase inhibitors staurosporine and genistein attenuated not only MIA-induced Bcl-2 phosphorylation but also cytotoxicity of MIA in Jurkat/CV, but not in Jurkat/TP. MIAs diminished expression of FasL in Jurkat/TP but not in Jurkat/CV, and neutralization of FasL by anti-FasL antibody considerably attenuated the cytotoxic effect of the MIAs in Jurkat/CV, but the effect of the antibody was marginal in Jurkat/TP cells. Our study provides further evidence that TP functions in conferring resistance on cancer cells to the stress induced by MIAs. In addition, we show that TP-induced inhibition of Bcl-2 phosphorylation and suppression of FasL may contribute to the protective function of TP in cancer cells.
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Authors
Hei-Cheul Jeung, Xiao-Fang Che, Misako Haraguchi, Tatsuhiko Furukawa, Chun-Lei Zheng, Tomoyuki Sumizawa, Sun-Young Rha, Jae Kyung Roh, Shin-ichi Akiyama,