Differential engagement of polar networks in the glucagon-like peptide 1 receptor by endogenous variants of the glucagon-like peptide 1

Article ID	Journal	Published Year	Pages	File Type
9004375	Biochemical Pharmacology	2018	35 Pages	PDF

Keywords

iCa2+PBS G Protein coupled receptors (GPCRs)DMEM FBS T2DM GLP-1 GPCR 3′,5′-cyclic adenosine monophosphate cAMP Dulbecco’s modified Eagle medium Biased agonism Cho Chinese Hamster Ovary Type 2 diabetes mellitus Receptor structure-function fetal bovine serum Cell signaling Phosphate buffered saline transmembrane helix Signal transduction PERK glucagon-like peptide-1 Intracellular calcium glucagon-like peptide-1 receptor G protein-coupled receptor

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Differential engagement of polar networks in the glucagon-like peptide 1 receptor by endogenous variants of the glucagon-like peptide 1

Authors

S.G.B. Furness, A. Christopoulos, P.M. Sexton, D. Wootten,