| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9006904 | Fitoterapia | 2005 | 6 Pages |
Abstract
In the present study, we investigated the effect of the dichloromethane fraction from Areca catechu nut on the severity of naloxone-precipitated morphine withdrawal in morphine-dependent mice. A single intraperitoneal injection of dichloromethane fraction at dose of 125 and 175 mg/kg significantly delayed the onset of withdrawal jumping behavior in a concentration-dependent manner compared to that of saline controls. The dichloromethane fractions also significantly decreased jumping numbers and faecal and urinary excretions during the withdrawal period.
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Authors
Ekkasit Kumarnsit, Niwat Keawpradub, Uraporn Vongvatcharanon, Kitja Sawangjaroen, Piyarat Govitrapong,