| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9007027 | Fitoterapia | 2005 | 9 Pages |
Abstract
In the pursuit of the anti-inflammatory constituents in lipophilic woad extracts, the 5-lipoxygenase (5-LOX) inhibitory activity was investigated by HPLC-based activity profiling. In a low-resolution profiling, two time windows with peaks of activity were found. The first coincided with tryptanthrin, a known dual inhibitor of cyclooxygenase-2 (COX-2) and 5-LOX, whereas the major inhibitory fraction was towards the end of the HPLC run. The active fractions were profiled in a peak-resolved manner, and the compounds analyzed by LC-MS, GC and TLC. The activity in the lipophilic fractions of the Isatis extract could be linked to an unsaturated fatty acid, α-linolenic acid.
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Authors
C. Oberthür, R. Jäggi, M. Hamburger,