Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9009679 | Journal of Ethnopharmacology | 2005 | 5 Pages |
Abstract
The anti-inflammatory activities of five flavonoids, namely 5,7-dimethoxyflavanone (1), 5,7-dimethoxy-3â²,4â²-methylenedioxyflavanone (2), isobonducellin (3), 2â²-hydroxy-2,3,4â²,6â²-tetramethoxychalcone (4) and bonducellin (5), all of them isolated from Caesalpinia pulcherrima L. was studied in lipopolysaccharide (LPS) and interferon (IFN)-γ activated murine peritoneal macrophages. These five compounds significantly and dose-dependently inhibited the inflammatory mediators; nitric oxide (NO), and cytokines [tumor necrosis factor (TNF)-α and interleukin (IL)-12]. According to their inhibitory results, the order of anti-inflammatory potency was compounds 3 > 5 > 4 > 2 > 1. Furthermore, peritoneal macrophages were pre-activated with LPS/IFN-γ for 24 h, and determined the inhibitory effects of the above-mentioned isolates on the production of NO after a further 24 h. The present study supports the use of Caesalpinia pulcherrima for the treatment of inflammatory diseases in traditional medicine. This is the first study on compounds 1-5 about their anti-inflammatory activities.
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Authors
Yerra Koteswara Rao, Shih-Hua Fang, Yew-Min Tzeng,