Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9009764 | Journal of Ethnopharmacology | 2005 | 7 Pages |
Abstract
Our results showed that TJ-9 at a dose of 0.5 g/(kg day) significantly reduced the serum level of PIII NP, the mRNA expression of TGF-β1 and PDGF. For the cytokines involved in the activation of Ito cell, TJ-9 at a dose of 0.5 g/(kg day) significantly suppressed the increasing tendency of IL-1β and enhanced the production of TNF-α. Finally, we concluded that: (1) TJ-9 at a dose of 0.5 g/(kg day) significantly reduced the serum fibrotic marker PIII NP in the bile duct ligated model, and its mechanism was partly by means of downregulating the mRNA of TGF-β1 and PDGF. These results also confirmed by the immunohistochemical staining of TGF-β1. (2) TJ-9 at a dose of 0.5 g/(kg day) suppressed the increasing tendency of IL-1β and stimulated the production of TNF-α to inhibit Ito cell proliferation and collagen formation.
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Authors
Ming-Ho Chen, Jung-Chou Chen, Chin-Chuan Tsai, Wen-Chuang Wang, De-Ching Chang, Dom-Gene Tu, Hsiao-Yen Hsieh,