Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9009781 | Journal of Ethnopharmacology | 2005 | 6 Pages |
Abstract
Caesalpinia bonducella F., is a shrub widely distributed throughout the coastal region of India and is ethnically used by the tribal people of Andaman and Nicober Island as a remedy of symptoms of diabetes mellitus. This ethnic report prompted the detail investigation of hypoglycemic activity of Caesalpinia bonducella seeds, initially on physiological hyperglycemic model and then on type 1 and type 2 sub-acute diabetic animal models which has already been reported. Evaluation of different extracts from Caesalpinia bonducella in chronic type 2 diabetic model alongwith insulin secretagogue activity of five fractions isolated from the Caesalpinia bonducella seed kernel are presented in this paper. Both the aqueous and ethanolic extracts showed potent hypoglycemic activity in chronic type 2 diabetic model. Two fractions BM 169 and BM 170 B could increase secretion of insulin from isolated islets.
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Authors
Shrabana Chakrabarti, Tuhin Kanti Biswas, Tapan Seal, Begum Rokeya, Liaquat Ali, A.K. Azad Khan, Nilufer Nahar, M. Mosihuzzaman, Biswapati Mukherjee,