Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9009799 | Journal of Ethnopharmacology | 2005 | 7 Pages |
Abstract
In this study, the anti-inflammatory, analgesic, and antipyretic effects of 50, 100 and 200Â mg/kg body weight of methanol extract obtained from Bauhinia racemosa stem bark, the so-called MEBR, were investigated. The effects of MEBR on the acute and chronic phases of inflammation were studied in carrageenan, dextran and mediators (histamine and serotonin)-induced paw oedema and cotton pellet-induced granuloma, respectively. Analgesic effect of MEBR was evaluated in acetic acid-induced writhing and hotplate tests. Antipyretic activity of MEBR was evaluated by yeast-induced hyperpyrexia in rats. The anti-oedema effect of MEBR was compared with 10Â mg/kg of indomethacin orally. In acute phase of inflammation, a maximum inhibition of 44.9, 43.2, 44.8 and 45.9% (PÂ <Â 0.001) was noted at the dose of 200Â mg/kg b.w. after 3Â h of treatment with MEBR in carrageenan, dextran, histamine and serotonin-induced paw oedema, respectively. Administration of MEBR (200Â mg/kg b.w.) and indomethacin (10Â mg/kg b.w.) significantly (PÂ <Â 0.05) decreased the formation of granuloma tissue induced by cotton pellet method at a rate of 50.4 and 56.2%, respectively. The extract also inhibited peritoneal leukocyte migration in mice. The MEBR also produced significant (PÂ <Â 0.01) analgesic activity in both models. Further, the MEBR potentiated the morphine- and aspirin-induced analgesic in mice. Treatment with MEBR showed a significant (PÂ <Â 0.01) dose-dependent reduction in pyrexia in rats. The results suggest that MEBR possess potent anti-inflammatory, analgesic and antipyretic activity.
Related Topics
Health Sciences
Pharmacology, Toxicology and Pharmaceutical Science
Pharmacology
Authors
M. Gupta, U.K. Mazumder, R. Sambath Kumar, P. Gomathi, Y. Rajeshwar, B.B. Kakoti, V. Tamil Selven,