Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9009803 | Journal of Ethnopharmacology | 2005 | 6 Pages |
Abstract
The estrogenic activity of 70% EtOH extracts of 32 traditional Chinese medicinal plants, selected according to their reported efficacy for the treatment of menopausal symptoms, was assessed using a recombinant yeast system with both a human estrogen receptor expression plasmid and a reporter plasmid. Among them, 11 (34%) species proved to be active. Polygonum cuspidatum had the highest estrogenic relative potency (RP) (3.28 Ã 10â3), followed by Rheumpalmatum (3.85 Ã 10â4), Cassia obtusifolia (3.49 Ã 10â4), Polygonum multiflorum (2.87 Ã 10â4), Epimedium brevicornum (2.30 Ã 10â4), Psoralea corylifolia (1.90 Ã 10â4), Cynomorium songaricum (1.78 Ã 10â4), Belamcanda chinensis (1.26 Ã 10â4), Scutellaria baicalensis (8.77 Ã 10â5), Astragalus membranaceus (8.47 Ã 10â5) and Pueraria lobata (6.17 Ã 10â5). The EC50 value of 17β-estradiol used as the positive control was 0.205 ± 0.025 ng/ml (RP = 100). This study gave support to the reported efficacy of Chinese medicines used for hormone replacement therapy.
Keywords
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Authors
C.Z. Zhang, S.X. Wang, Y. Zhang, J.P. Chen, X.M. Liang,