Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9011369 | Journal of Ethnopharmacology | 2005 | 5 Pages |
Abstract
The molecular mechanism of the Chinese traditional medicine 'Bushen Yinao Pian' (a complex prescription used for clinical anti-ageing in China for over 20 years) is elusive. In this study, the cDNA of low-density lipoprotein related-receptor associated protein-1 (LRPAP-1), an ageing-related gene, which functions as a chaperon or escort protein in the intracellular transport of low-density lipoprotein related-receptor, a transporter of amyloid beta protein (AβP), had been cloned by screening cDNA library based on analyzing the gene expression in cerebral tissue between the test and the control accelerated senescence-prone mouse 8/Ta (SAMP8/Ta). The result shows that this complex prescription increased the expression level of LRPAP-1. It indicated that the Chinese traditional medicine 'Bushen Yinao Pian' plays an important role in anti-ageing by increasing LRPAP-1 expression level.
Keywords
DDRT-PCRX-GaldNTPdCTPIPTGLRPM-MuLVAMPAβPRAPcDNAComplementary DNADNAAmpicillindeoxyribonucleic acidRNAribonucleic acidGene expressionAlzheimer's diseasedeoxycytidine triphosphatedeoxynucleoside triphosphateCNSLuria-Bertani mediumreverse transcriptioncentral nervous systemAnti-ageingChinese traditional medicineLow-density lipoproteinLDLCSFCerebrospinal fluidpolymerase chain reactionPCRMoloney murine leukemia virusamyloid beta proteinreceptor associated protein
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Authors
Chong Zhang, Ting Yang, Jingang Wang, Guisheng Liu, Qingxuan Chen,