| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9011388 | Journal of Ethnopharmacology | 2005 | 6 Pages |
Abstract
Shiquandabutangjiaweibang (SDJ) is a traditional medicine prescription used for increasing body resistance against cancer. In the present study, the effect of SDJ extract on tumor metastasis and angiogenesis was evaluated. SDJ showed cytotoxicity against P388 (leukemia cells) and B16-F10 (murine melanoma cells) to 60% of control at 1Â mg. SDJ significantly inhibited lung metastasis and also restored the number of platelets in C57BL/6 mice with thrombocytopenia induced by intravenous injection of B16-F10 cells. SDJ significantly disrupted chick embryonic angiogenesis in the chorioallantoic membrane (CAM). Interestingly, SDJ suppressed DNA topoisomerase I in a concentration-dependent manner. These results suggest that SDJ can be a potent inhibitor of metastasis and angiogenesis, at least in part, via regulation of topoisomerase I.
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Authors
Sung Hoon Kim, Tae-Hyung Lee, Deok-Chun Yang, Hyung-Min Kim, Jeung-Beum Kim, Mi-Kyung Park, Yong-Soo Bae,