Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9011398 | Journal of Ethnopharmacology | 2005 | 6 Pages |
Abstract
The butanolic fraction of dried leaves of Acacia pennata (Mimosaceae) was tested for analgesic and anti-inflammatory activities in animal models. It showed significant protective effects against chemical stimuli (acetic acid and formalin) in the mouse. It also produced a significant increase of the threshold of sensitivity to pressure-induced pain in the rats. The extract revealed an inhibitory effect in carrageenin-induced rat paw oedema in the late phase. The results suggested that a peripheral mechanism is involved in the analgesic, associated to anti-inflammatory effect (NSAIDs-like). Among the class of compounds characterized in this fraction, flavonoids may be mainly responsible for the pharmacological activities.
Keywords
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Authors
A.B. Dongmo, T. Nguelefack, M.A. Lacaille-Dubois,