| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9012244 | Journal of Pharmacological and Toxicological Methods | 2005 | 9 Pages |
Abstract
Our results on HR, blood pressure, and ECG obtained after i.v. administration of reference compounds show the usefulness of the guinea pig in assessing cardiovascular safety. The anaesthetized guinea pig allows the measurement of cardiac contractility and the use of doses higher than in conscious animals. Using this animal model, several cardiovascular parameters can be recorded simultaneously at a modest cost in terms of test compound and the number of animals required.
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Authors
Daniela S. Hauser, Matthias Stade, Angela Schmidt, Guido Hanauer,