| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9012287 | Journal of Pharmacological and Toxicological Methods | 2005 | 10 Pages |
Abstract
The use of liver slices in combination with TaqMan technology provides a good model for predicting CYP induction in the rat. This method is useful for identifying compounds with CYP2B and 3A induction liability in the early phase of drug discovery.
Keywords
PCNPRODCytochrome P450 inductionpregnenolone 16α-carbonitrilePXRNCESMGBHPBCDPPARRT-PCRCyPAHRReal-time PCRSafety pharmacologyMethodCytochrome P450PhenobarbitalCARRatPolycyclic aromatic hydrocarbonsPAHsHydroxypropyl-β-cyclodextrinnew chemical entitiesreverse transcription-polymerase chain reactionMinor groove bindingaryl hydrocarbon receptorconstitutive androstane receptorPeroxisome proliferator activated receptorPregnane X receptor
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Authors
Xiaoming Cui, Ann Thomas, Yi Han, Jairam Palamanda, Diana Montgomery, Ronald E. White, Richard A. Morrison, K.-C. Cheng,