| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9014919 | Pharmacological Research | 2005 | 7 Pages |
Abstract
The present data suggest that sensitisation of 5-HT2C receptor-mediated intracellular signal transduction may play a role in the effects of citalopram. In contrast, fluoxetine treatment does not functionally sensitise 5-HT2C receptors. Thus, functional 5-HT2C receptor sensitisation is not a common effect of antidepressants, but the differential effects may explain some of the pharmacodynamic differences seen with these drugs, especially upon repeated administration.
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Authors
Esa-Pekka Pälvimäki, Hannu Majasuo, Erkka Syvälahti, Jarmo Hietala,