| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9015012 | Pharmacological Research | 2005 | 7 Pages |
Abstract
In conclusion, our results indicate that histamine-induced vasodilatation in the perfused kidney of the STZ-induced diabetic rats is mediated by the two vasodilator components, namely EDHF and EDNO. The EDHF component was not significantly affected by diabetes. However, histamine-induced vasodilatation mediated by the EDNO component was more significantly reduced in diabetic rats. Results have also indicated that the EDHF component of histamine-induced vasodilatation was mediated through Ca2+-activated K+ channels in perfused kidney preparations from both control and diabetic rats.
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Authors
Mariam H.M. Yousif,