Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9015974 | Pharmacology & Therapeutics | 2005 | 31 Pages |
Abstract
The physiological function(s) of FMO are poorly understood. Three of the 5 expressed human FMO genes, FMO1, FMO2 and FMO3, exhibit genetic polymorphisms. The most studied of these is FMO3 (adult human liver) in which mutant alleles contribute to the disease known as trimethylaminuria. The consequences of these FMO genetic polymorphisms in drug metabolism and human health are areas of research requiring further exploration.
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Authors
Sharon K. Krueger, David E. Williams,