Genetic variation in the hepatic lipase gene is associated with combined hyperlipidemia, plasma lipid concentrations, and lipid-lowering drug response

A higher frequency of the −514T allele of LIPC suggests a role of this locus in the pathogenesis of CHL. The −514T allele is associated with higher HDL-C concentration in normolipidemic population. The −514C→T polymorphism modulates the lipid-lowering response to bezafibrate, with a better effect in homozygous CC subjects.