Temporal variation in inhospital mortality with percutaneous coronary intervention: A report from the National Heart, Lung and Blood Institute Dynamic Registry

There is a significant time-dependent variation in the risk of inhospital PCI-related mortality during usual working hours. The highest risk period, taking into account numerous factors that confound this association, is the latter part of the workday. A second period of apparent greater risk occurs during the early part of the workday and is consistent with our present understanding of circadian variation in cardiovascular disease processes.