| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9171672 | Journal of Electrocardiology | 2005 | 6 Pages |
Abstract
The impact of sotalol, ibutilide, flecainide, and quinidine on QT prolongation has been evaluated. But only quinidine effectively suppressed gain-of-function in IKr, along with prolongation of the QT interval. Furthermore, in patients with a mutation in HERG (SQT1), quinidine rendered ventricular tachyarrhythmias noninducible and restored the QT interval/heart rate relationship toward a reference range. It may serve as an adjunct to ICD therapy or as possible alternative treatment especially for children and newborns.
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Authors
Martin MD, Christian MD, Charles MD, Christian MD, Carla MD, Fiorenzo MD, Rainer MD,