| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9186144 | Trends in Cardiovascular Medicine | 2005 | 9 Pages |
Abstract
The expression of a subset of genes is strongly controlled at translational checkpoints, a major mechanism of posttranscriptional regulation. Inflammatory and vascular cells receive outside-in signals to specialized pathways that regulate translation of specific messenger RNAs in a transcript-specific fashion and thereby influence key features of cellular phenotype. These pathways and the expression of proteins that they control may be dysregulated in cardiovascular diseases and are therapeutic targets.
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Authors
Stephan W. Lindemann, Andrew S. Weyrich, Guy A. Zimmerman,