Article ID Journal Published Year Pages File Type
9194467 Journal of Neuroimmunology 2005 9 Pages PDF
Abstract
The findings of the present study indicate that chronic exposure to HC diet increases the expression of the two important inflammatory mediators IL-6 and caspase-1 in the brain of KO and WT mice. In the case of caspase-1, we report a major difference in the effect of HC diet on the KO mice compared to WT mice in the hippocampus. Increased expression of inflammatory mediators involved in neurodegeneration could be a potential mechanism by which hypercholesterolemia and HC diet increase the risk of AD.
Related Topics
Life Sciences Immunology and Microbiology Immunology
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