Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9194518 | Journal of Neuroimmunology | 2005 | 7 Pages |
Abstract
Pixantrone is an immunesuppressor similar to mitoxantrone but with lower cardiotoxicity. We evaluated the effect of pixantrone on B cells and lymphomononuclear cells in the course of acute EAE. Pixantrone reduced the number of B cells and suppressed myelin basic protein (MBP) specific IgG production. In vitro, pixantrone induced apoptosis of rat B lymphocytes in a way similar to mitoxantrone. In addition, pixantrone inhibited antigen specific and mitogen induced lymphomononuclear cell proliferation, as well as IFN-γ production, during EAE. These findings suggest a similar mechanism of action for pixantrone and mitoxantrone on the effector function of lymphomonocyte B and T cells.
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Authors
Benedetta Mazzanti, Tiziana Biagioli, Alessandra Aldinucci, Guido Cavaletti, Ennio Cavalletti, Norberto Oggioni, Maura Frigo, Stefania Rota, Elena Tagliabue, Clara Ballerini, Luca Massacesi, Paolo Riccio, Francesco Lolli,