Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9194524 | Journal of Neuroimmunology | 2005 | 4 Pages |
Abstract
Interleukin 4 is a Th2 cytokine with potent anti-inflammatory properties. Protection from autoimmune encephalomyelitis and multiple sclerosis has been achieved with IL-4 therapy and IL-4 deficient mice developed a more severe form of clinical disease. Four polymorphisms within the IL-4 gene are in strong linkage disequilibrium, including one in the promoter at â 590, which controls transcriptional activity. An MS protective role for the heterozygous genotype was confirmed in Spain (exon-1 + 33 C/T: p = 0.003, OR [CI] = 0.57 [0.38-0.84]), probably indicative of an MS protection haplotype at 5q31 locus. No difference among MS clinical forms or age at onset was detected.
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Authors
Elena Urcelay, Jose Luis Santiago, Ana Mas, Alfonso MartÃnez, Virginia de las Heras, Rafael Arroyo, Emilio G. de la Concha,