Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9194526 | Journal of Neuroimmunology | 2005 | 8 Pages |
Abstract
Subcutaneous Interferon-β (IFN-β) injections for the treatment of multiple sclerosis (MS) frequently cause inflammatory injection site reactions. To study the role of chemokines we obtained skin biopsies from 7 MS patients 24 h after injection. At the IFN-β but not at the contralateral placebo injection sites, we observed strong IP-10/CXCL10 and moderate MCP-1/CCL2 expression associated with extensive perivascular, highly CXCR3-positive T cell and macrophage infiltrates. Primary human skin cells displayed a comparable pattern of chemokine induction after stimulation with IFN-β in vitro. IFN-β may therefore trigger inflammatory skin reactions through local chemokine induction followed by rapid immune cell extravasation.
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Authors
Mathias Buttmann, Matthias Goebeler, Atiye Toksoy, Sybille Schmid, Wolfgang Graf, Friederike Berberich-Siebelt, Peter Rieckmann,