Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9194531 | Journal of Neuroimmunology | 2005 | 11 Pages |
Abstract
The ability to expand human neural precursor cells in vitro offers new possibilities for future cell therapies. However, concern over immunologically based rejection of in vitro-expanded human neural cells confounds their use as donor cells. Here, we demonstrate that the expression of human leukocyte antigen (HLA) class I and II molecules, but not the co-stimulatory proteins CD40, CD80 and CD86, substantially increase during expansion of neurospheres. Furthermore, peripheral lymphocytes were unresponsive when co-cultured with in vitro-expanded neural cells. Taken together, these results suggest a low immunogenicity of these cultured human neural cells despite HLA incompatibility and high HLA expression.
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Authors
Jenny Odeberg, Jing-Hua Piao, Eva-Britt Samuelsson, Scott Falci, Elisabet Ã
kesson,