Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9194546 | Journal of Neuroimmunology | 2005 | 10 Pages |
Abstract
Ocular inflammation is a common cause of retinal edema that may involve swelling of Müller glial cells. In order to investigate whether endotoxin-induced ocular inflammation in rats alters the swelling and membrane characteristics of Müller cells, lipopolysaccharide (LPS; 0.5%) was intravitreally injected. At 3 and 7 days after treatment, hypotonic challenge induced swelling of Müller cell somata that was not observed in non-treated control eyes. Müller cells of LPS-treated eyes displayed a downregulation of inward K+ currents and upregulation of A-type K+ currents that was associated with a decreased expression of Kir4.1 protein in retinal slices. The data suggest that ocular inflammation induces alterations of both the swelling characteristics and the K+ channel expression of Müller cells.
Related Topics
Life Sciences
Immunology and Microbiology
Immunology
Authors
Thomas Pannicke, Ortrud Uckermann, Ianors Iandiev, Peter Wiedemann, Andreas Reichenbach, Andreas Bringmann,